PHARMACEUTICAL AEROSOLS – ENHANCING THE .
small grinding media and the liquid medium, produce submicron or nanosize particles. The specific media milling processing developed for this research was designed to operate at high pressures, allowing preparation of dispersions using the propellant itself as the milling medium. This highpressure media milling (HPMM) process yields stable, fine particle dispersion of medicament in liquid HFC propellant.